This was a trip I made in June 2018 in glorious weather, and involved a first journey on the direct London to Amsterdam Eurostar, staying in Breukelen near Utrecht for three nights then on to Ghent via Antwerp for a night.
You can get more details on the trip by clicking the links below :
London to Amsterdam via Eurostar (direct), then local train to Breukelen
Breukelen to Ghent via local train to Rotterdam, NS InterCity to Antwerp then Belgian IC to Ghent
Ghent to London via local train to Brussels, then Eurostar