You leave from the underground platforms of Berlin main station on a EuroCity train – not as modern as some of the German ICE’s but perfectly comfortable – and I was travelling first class (for only 10 euro more, as I recall).
The journey as far as Dresden is fairly unremarkable, so I took the opportunity to have lunch in the restaurant car. However south of Dresden the scenery is wonderful as the train runs alongside the Elbe river (cover photo and below). Castles, churches and pretty villages line the banks of the river – try and get a seat on the left hand side of the train (when travelling towards Prague) for the best views.
Travelling solo throws you into the path of all sorts of people – I had an entertaining conversation with a gay couple from Canada sat opposite me while the train flew past rural Czech stations as we neared Prague.
Four hours and twenty minutes later after leaving Berlin we arrived at Praha hlavní nádraží – also known as Prague main station – located to the north of the city centre about 15 minutes from Wenceslas Square.